An outstanding characteristic of all neoplasms is their tendency to reproduce to a limited extent the design and function of the parent tissue, emphasizing the importance of histogenesis in the interpretation of their pathology. In tumors of the giant cell group, attention on the pathologic side has been directed usually to only the histologic appearances of these lesions, and because of this shortcoming, much confusion has arisen in classifying these growths, the microscopic resemblance of some of these tumors to granulation tissue having led to a seemingly endless debate regarding their inflammatory or neoplastic nature. In the studies summarized in this article, attention has been directed to the histogenic rather than to the histologic aspects of these lesions, and by an analysis which traces the origin of these tumors to embryonic functions, a fundamental pathologic relationship has been established between various forms of giant cell tumors heretofore considered under separate
GESCHICKTER CF, COPELAND MM. TUMORS OF THE GIANT CELL GROUP: A PATHOLOGIC ENTITY. Arch Surg. 1930;21(1):145–156. doi:10.1001/archsurg.1930.01150130148008
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