In the routine microscopic examination of goiters removed at operation, one occasionally finds small nodules which are composed of epithelioid cells and giant cells. These nodules occur in the diffuse enlargements of the gland as well as in the circumscribed, nodose hyperplasias. In the nodose goiters, they may be located in the nodes or outside in their vicinity in which location they are most frequent. A considerable literature has been devoted to the nodules, and because of their morphologic similarity to miliary tubercles they are usually considered as such. In the older literature on the morbid anatomy of the thyroid gland, tuberculosis is described as being rare. Rokitansky never saw tuberculosis of the thyroid, and according to Virchow no other gland is as seldom affected by tuberculosis as is the thyroid. In miliary tuberculosis, however, the thyroid frequently is the site of tubercles which do not differ from the tubercles
JAFFÉ RH. TUBERCLE-LIKE STRUCTURES IN HUMAN GOITERS. Arch Surg. 1930;21(5):717–728. doi:10.1001/archsurg.1930.01150170003001
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