In December, 1928,1 we reported before this association, sixty-one cases of tumor of the colon resected after the patients had had the benefit of cooperative management of a medical and a surgical service. Among the details of the treatment, intraperitoneal vaccination was considered one of the essentials. The striking reduction in mortality in this group over the control group, in which operation was performed by the same surgeons under the same circumstances, increased our belief that this was an important detail in guarding against the peritonitis which is the customary cause of death in more than half of these cases.
Our efforts to ascertain more closely the merits of intraperitoneal vaccination, as applied clinically, were stimulated by the experimental work of Herrmann2 in 1928. We carried this work forward and by Oct. 1, 1929, we had increased to 300 the series of cases in which vaccination and operation
RANKIN FW, BARGEN JA. VACCINATION AGAINST PERITONITIS IN SURGERY OF THE COLON: FURTHER REPORT. Arch Surg. 1931;22(1):98–105. doi:10.1001/archsurg.1931.01160010103006
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