In the normal person or animal, following hemorrhage there occurs a passage of some fluid from the tissue spaces into the blood stream, thereby resulting in a dilution of the blood. Starling1 believed this to be due to such reduction of the filtration pressure in the capillaries that the osmotic pressure of the plasma proteins is no longer counterbalanced. Cannon2 stated that it is one of the unexplained features of shock not due to hemorrhage that with the low venous and arterial pressure this process does not occur. Some information in this respect has been reported in previous papers of this series. The amount of whole blood or of plasma that was lost from the blood stream at the site of injury was determined after severe trauma to an extremity,3 after trauma to the intestines,4 after mild trauma to an extremity5 and after burns.6
HARRIS PN, BLALOCK A. EXPERIMENTAL SHOCKX. OBSERVATIONS ON THE WATER CONTENT OF THE TISSUES OF THE BODY AFTER TRAUMA AND AFTER HEMORRHAGE. Arch Surg. 1931;22(4):638–648. doi:10.1001/archsurg.1931.01160040114008
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