Primary tumors of the bone characterized histologically by an unorganized growth of round cells, without appreciable intercellular substance, occupy an uncertain position among malignant neoplasms of the bone. In the literature one may find such varied designations of these tumors as "solitary myelomas," "undifferentiated osteogenic sarcomas," "round cell sarcomas of bone," "endotheliomas," "cellular medullary tumors," "embryonal tumors of bone marrow" and "myelosarcoma." Ewing's sarcoma, apparently a homogeneous clinical entity, has but recently1 been segregated from this ill-defined category of tumors.
We have recently studied the available literature on primary tumors of the bone in connection with a confusing tumor of the humerus, removed from a patient of one of us (H. McK.), which clearly originated as a complication of preexisting cystic disease of the same locality. This tumor had microscopic characters in common with the group of myelomas, while a disseminated scanty fibrous, hyaline and osteoid intercellular substance and
HARMON PH, McKENNA H. PRIMARY MYELOGENOUS SARCOMA COMPLICATING CYSTIC DISEASE OF THE HUMERUS: REPORT OF A CASE. Arch Surg. 1931;22(6):903–925. doi:10.1001/archsurg.1931.01160060031002
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