Lipogranulomatosis is a rather common disease which is frequently overlooked and misinterpreted. A description of the individual lesions, the whole chain of which constitutes the entity of the disease described by Makai,1 is repeatedly met with in the literature of the last twenty years. According to Makai, the lesion is due to necrosis of the subcutaneous fat tissue, transformation of its neutral fats into fatty acids or soaps and inflammatory reaction of the surrounding tissue. The result is a granulation tissue, frequently of epithelioid cell character, suggestive of tuberculosis. This similarity is further stressed by the large number of giant cells, some of which are of the ordinary foreign body type, while others are of the characteristic Langhans type. The granulation tissue is finally substituted by fibrous scar tissue in which inclusions of necrotic and even calcified material are met with; or the scar tissue encloses cystlike cavities, the
GOLDZIEHER MA. LIPOGRANULOMATOSIS (MAKAI). Arch Surg. 1931;23(4):690–702. doi:10.1001/archsurg.1931.01160100149005
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