The research a preliminary report of which is here presented was undertaken with the purpose of discovering some physical principle that might account for the conversion of normal cells into cancer cells, that is, into cells the energy of which is used only for growth, whereas the energy of the tissue in which the conversion takes place is used primarily for function. It is clear that the cancer cell must owe its formation to the operation of existing laws of growth in the host. These laws are most strikingly illustrated in the process of fertilization.
The ovum and the sperm, as Keller has shown, exhibit opposite signs of charge, hence they attract each other. The preponderantly positive element exists apart from the preponderantly negative element, but when they unite growth and division take place, forming the beginning of a new organism. The fertilized ovum contains, therefore, elements bearing opposite signs
CRILE GW, TELKES M, ROWLAND AF. THE NATURE OF LIVING CELLS: WITH SPECIAL REFERENCE TO THE NATURE OF CANCER CELLS AND OF FATTY DEGENERATION. Arch Surg. 1931;23(4):703–714. doi:10.1001/archsurg.1931.01160100162006
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