[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.225.194.144. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
December 1931

PAGET'S DISEASE: A PREDISPOSING FACTOR TO OSTEOGENIC SARCOMA

Author Affiliations

NEW YORK
From the Department of Bone Tumors, Memorial Hospital.

Arch Surg. 1931;23(6):918-936. doi:10.1001/archsurg.1931.01160120032002
Abstract

The frequent association of Paget's disease and osteogenic sarcoma in patients over 50 years of age has attracted the attention of other observers. Our interest was aroused because of three cases recently coming under our observation, and a careful study of the subject was undertaken. We would reiterate Codman's1 suggestion that such cases deserve a separate division in the Registry classification because of their different clinical features. It seems to us also that this group may be important in giving a clue to one of the etiologic factors of osteogenic sarcoma. We know of no instance of the development of a benign giant cell tumor or endothelial myeloma occurring in a bone that was the site of a preexisting Paget's disease.

For a clear understanding of the problem, it has seemed advisable to summarize briefly some of the known facts concerning Paget's disease.

DESCRIPTION OF OSTEITIS DEFORMANS  Sir James

×