During the past year Raiziss, Severac and Moetsch1 reported that solutions of metaphen, applied on gauze for five minutes in strengths ranging from 1: 500 to 1: 2,500, produced complete sterilization of the skin of rabbits contaminated with broth cultures of Staphylococcus aureus, Streptococcus hemolyticus and Bacillus subtilis after preliminary cleansing. White and Hill,2 however, questioned the results on the basis that the drug was transferred from the skin to the subcultures in amounts sufficient to inhibit bacterial growth in the medium, thereby leading to the erroneous supposition that metaphen had completely sterilized the skin. Since they stated that metaphen in the dilution 1: 500 cannot be relied on regularly to sterilize normal human skin after an exposure of five minutes, and since the subject of disinfection of the skin is one of great practical importance, especially in relation to surgery, we have thought it advisable to repeat
KOLMER JA, HARKINS MJ. METAPHEN AS A DISINFECTANT OF THE SKIN. Arch Surg. 1931;23(6):1007–1012. doi:10.1001/archsurg.1931.01160120121007
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