As has been suggested by many workers, in cases of high intestinal obstruction there are two fairly well defined groups of factors that probably operate in the pathogenesis of the untoward symptoms that develop. Dehydration, with loss of chlorides and other constituents of gastro-intestinal and pancreatic secretions either by vomiting or by failure of reabsorption, on the one hand, and toxemia from the absorption of toxic substances from the intestinal lumen, on the other hand, may operate more or less independently at times, but probably more often concurrently and with a reciprocal influence in the usual case.
In an analysis of some of the factors concerned in intestinal obstruction, Haden and Orr,1 in 1923, produced various types of experimental obstruction of the cardia and esophagus and reported that severe toxemia with rapid death resulted. They ascribed the symptoms and death to the same causes that were thought by them
CARL A. DRAGSTEDT, RALPH B. MULLENIX. EXPERIMENTAL ESOPHAGEAL OBSTRUCTION. Arch Surg. 1932;24(1):152–157. doi:10.1001/archsurg.1932.01160130155011