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Article
March 1932

INCIDENCE OF NODULES IN THE THYROID: A COMPARATIVE STUDY OF SYMPTOMLESS THYROID GLANDS REMOVED AT AUTOPSY AND HYPERFUNCTIONING GOITERS OPERATIVELY REMOVED

Author Affiliations

MINNEAPOLIS
From the Department of Surgery, University of Minnesota.

Arch Surg. 1932;24(3):505-515. doi:10.1001/archsurg.1932.01160150168008
Abstract

The presence of nodules within an otherwise normal thyroid gland is well recognized. Whether or not these nodules have any definite significance has long been a debated question. It has been thought that they represent developmental processes that occur in the natural course of development and indicate no significant feature. They have also been considered as involutional bodies, representative of the stages in hyperthyroid diseases, and they have been looked on as true tumors arising from germinal centers and having the significance of benign neoplasms. Whichever may be the case, their definite significance has never been proved.

If one is to establish the normal for a given district by assuming that the majority represents the normal, then one must accept the presence of nodules in the thyroid gland as a normal characteristic in Minnesota. It is, however, more probable that these nodules represent an attempt to establish a physiologically normal

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