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April 1932


Author Affiliations

From the Surgical Pathological Laboratory of the Johns Hopkins Hospital and University.

Arch Surg. 1932;24(4):602-659. doi:10.1001/archsurg.1932.01160160074007

INTRODUCTION  Emphasis is repeatedly placed on the lawlessness of cancer and its defiance of growth restraint. However, the diagnostic features of the disease, the establishment of well defined clinical entities under this category, as well as the uniform gravity of the prognosis, all point to the reverse of this statement, indicating that the biology of malignancy conforms to definite and rigorous laws. The repetition to a fair degree of the design and physiology of the parent tissue by the neoplastic growth suggests that the tumor in its development repeats the normal histogenesis of the part affected. An analysis of these normal histogenetic processes, usually neglected in pathology, should therefore prove most significant in a study of the origin of various forms of tumors.In a study of osteogenic sarcoma, which is one of the more variable tumors in which chaotic distortion of normal development has been much stressed (Putti1