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Article
May 1932

ACUTE AND SUBACUTE ATROPHY OF THE LIVER AND THE EVOLUTION OF TOXIC CIRRHOSIS: A REVIEW OF TWENTY-TWO CASES

Arch Surg. 1932;24(5):775-797. doi:10.1001/archsurg.1932.01160170062004
Abstract

This paper is based on a clinical and pathologic study of twenty-two cases of atrophy of the liver. The cases have been selected as characteristic of the type of atrophy commonly designated as yellow or red atrophy of the liver (Rokitansky), and are illustrative, both clinically and pathologically, of the various stages of this type of hepatic disease.

GENERAL COMMENT 

Classification.  —Based on anatomic considerations, the three stages or degrees of atrophy of the liver1 are: acute, subacute and chronic. The microscopic anatomy seen in the acute stage was characterized by extensive necrobiosis of the hepatic cells. The subacute stage followed when clearing of the cellular detritus of the acute cytolytic process appeared completed; this left a disorganized liver in which there was only partial preservation of the parenchyma. Owing to the extensive loss of hepatic cells, the hepatic stroma was brought into prominence. The chronic stage was characterized

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