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Article
August 1932

GASTRIC ACIDITY WITH SPECIAL REFERENCE TO THE PARS PYLORICA AND PYLORIC MUCOSA: AN EXPERIMENTAL STUDY

Author Affiliations

ROCHESTER, MINN.
From the Division of Experimental Surgery and Pathology, the Mayo Foundation.

Arch Surg. 1932;25(2):395-403. doi:10.1001/archsurg.1932.01160200140007
Abstract

GASTRIC ACIDITY FOLLOWING RESECTION OF THE PARS PYLORICA  The cause of the lowered gastric acidity following gastric resection on the human being has been intensively studied, and although many hypotheses have been offered in explanation, as yet none has been satisfactory. Many observers state that the lowered acidity results from loss of the pars pylorica, which they credit with great significance in the regulation of gastric secretion. Our investigations, which were conducted entirely on dogs, were undertaken with the purpose of attempting to evaluate this supposed function of the pyloric mucosa more accurately.Few, if any, surgeons still disagree with anatomists by stating that acid-forming glands are removed when only the pars pylorica is resected;1 likewise, few accept the existence of a "nerve center" in the region of the incisura supposedly essential for normal gastric secretion.2 The reason often advanced for the decreased acidity following resection of the

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