This paper is a continuation of previously reported studies1 of the effects of the administration of fluids to animals with low blood pressure. In the previous studies, fluid was administered intravenously and subcutaneously. The changes observed in the protein content of the blood were considered important. The present studies were carried out in order to determine the effects of physiologic solution of sodium chloride when introduced by intraperitoneal injection and by stomach tube into animals with low blood pressure. The subcutaneous injection of histamine and graded bleeding were the methods used to produce low blood pressure.
All of the experiments were carried out on dogs that were anesthetized with morphine. They gave no evidence of pain during the experiments. Shortly following the administration of the anesthetic, the blood volume was determined by the dye method,2 and samples of blood were withdrawn for the control determinations. Physiologic solution
BEARD JW, WILSON H, BLALOCK A. EFFECTS ON COMPOSITION OF BLOOD OF PHYSIOLOGIC SOLUTION OF SODIUM CHLORIDEWHEN INTRODUCED BY INTRAPERITONEAL INJECTION AND BY STOMACH TUBE IN THE PRESENCE OF LOW BLOOD PRESSURE. Arch Surg. 1933;26(1):122–133. doi:10.1001/archsurg.1933.01170010125011
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