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Article
March 1933

BREAKING STRENGTH OF HEALING FRACTURED FIBULAE OF RATS: VI. OBSERVATIONS ON THE INFLUENCE OF BILATERAL OVARIECTOMY

Author Affiliations

Davis and Geck Fellow in Surgery; Research Assistant in Surgery NEW HAVEN, CONN.
From the Department of Surgery, Yale University School of Medicine.

Arch Surg. 1933;26(3):430-442. doi:10.1001/archsurg.1933.01170030087006
Abstract

The ovaries of the female are concerned not only with the regenerative functions of the animal, but also to no small extent with its metabolism in general. The influence exerted by the ovaries on the growth and repair of bone is incompletely understood, and little work has been done on this aspect of the problem. For this reason we decided to determine the effect of bilateral ovariectomy on the breaking strength of fractured and unfractured fibulae of rats.

Marsiglia,1 estimating the process of calcification in fractured bones by means of roentgenograms, was unable to demonstrate that extirpation of the ovaries influenced the formation of the callus. Reach2 found a slight reduction in the calcium oxide content of the skeleton of mice following the removal of the ovaries, and Korenchevsky3 was unable to find any essential difference by chemical or histologic examination in the skeletons of growing rats

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