The late Sir James Mackenzie is reputed to have said that discussions on angina pectoris are usually futile, as they simply consist of the replacement of one speculative hypothesis by another. This has been true both as to the etiology of the disease and as to the most logical surgical method of preventing the attacks. It is not within the scope of this paper to review the multitudinous theories which have been put forward to explain the cause of these painful crises; suffice it to say that by their very number Mackenzie's dictum has remained substantiated for many years. Recently, however, an increasing number of cardiologists have subscribed to the theory of Keefer and Resnik,1 that most cases of angina pectoris can be accounted for on the basis of anoxemia of the myocardium. The experiments of Sutton and Lueth2 have given strong support to this theory of the
WHITE JC, GARREY WE, ATKINS JA. CARDIAC INNERVATION: EXPERIMENTAL AND CLINICAL STUDIES. Arch Surg. 1933;26(5):765–786. doi:10.1001/archsurg.1933.01170050033003
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