In the earlier stages extension of lymphosarcoma may take place through the lymphatics, but in advanced cases many of the organs show apparently true metastatic growths which are satisfactorily explained only on the basis of invasion of the blood vessels.1 Reports of cases from the literature illustrate a direct extension of the disease to bones as well as hematogenous metastases.2 Reports of larger groups of patients yield little or no information as to the incidence of involvement of the bone in lymphosarcoma.3
The records of the Memorial Hospital for the Treatment of Cancer and Allied Diseases made available for analysis one hundred and sixty four cases in which the diagnosis of lymphosarcoma was established by biopsy or at autopsy. Seventeen patients (10.4 per cent) were found to have involvement of the bone. In every instance the changes were demonstrable prior to death.While the duration
CRAVER LF, COPELAND MM. LYMPHOSARCOMA IN BONE. Arch Surg. 1934;28(5):809–824. doi:10.1001/archsurg.1934.01170170002001
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