During the past few years, in connection with other investigations, I examined a number of animals deprived of their pancreatic secretions by means of fistulas, ligation of the pancreatic ducts and pancreatectomy and was impressed by the infrequent occurrence of peptic ulcers in these animals compared with dogs in which bile was excluded. In 1926, Kapsinow1 produced duodenal ulcers in seventeen of forty-three dogs by excluding bile from the intestine by means of cholecystonephrostomy, with ligation and division of the common duct. In 1930, Berg and Jobling2 observed that peptic ulcers developed in ten of twenty-three dogs with biliary fistulas and biliary obstruction. Bollman and Mann3 reported the occurrence of peptic ulcers in sixty-four of eighty-seven dogs with jaundice after ligation of the common duct. Kim and Ivy4 found ulcers in six of ten dogs with biliary fistulas. Loewy5a observed duodenal ulcers in three of
BERG BN. PEPTIC ULCERS: COMPARATIVE FREQUENCY AFTER DEPRIVATION OF BILE AND PANCREATIC JUICE. Arch Surg. 1934;28(6):1057–1061. doi:10.1001/archsurg.1934.01170180059002
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