The question of the influence of circulatory changes on the healing of bone has been discussed by many authors with conflicting opinions. Pearse and Morton1 and McMaster and Roome2 have offered experimental evidence that the healing of defects of bones is accelerated by venous stasis. On the other hand, sympathectomy, with its increased flow of blood in the extremity, has been empirically advocated in the treatment of fractures by Leriche,3 Colp and Mage4 and others. Pearse and Morton,5 Key and Moore6 and McMaster and Roome2 found no experimental confirmation of the value of such therapy. Clinically, certain atrophies of bone are explainable on the basis of arterial hyperemia (Greig7). Harris8 listed several conditions known to cause hypertrophy and lengthening of the bones of children in which various degrees of venous stasis exist.
Formation of bone may be initiated by the transplantation
ROOME NW, McMASTER PE. INFLUENCE OF VENOUS STASIS ON HETEROTOPIC FORMATION OF BONE. Arch Surg. 1934;29(1):54–58. doi:10.1001/archsurg.1934.01180010057007