The results obtained at the Stanford University Clinics following therapeutic thrombosis of varicose veins by the injection of sclerosing solutions were reported in 1931.1 Careful examination a year or more following thrombosis disclosed recanalization or recurrence in the thrombosed veins in 98 per cent of all patients examined. In spite of the recurrence of varicosities and recanalization of veins, 54 per cent of the patients had complete relief of all symptoms attributed to the presence of the varicosities and 94 per cent obtained partial or complete relief of symptoms during the period of observation. That the recurrence was due to recanalization of the thrombus, and not to the formation of new veins or enlargement of collateral venous channels, was shown by a microscopic study of veins excised at intervals following thrombosis by injection, and by personal observation and comparison of the recurrent varicose veins with the charted positions of
HOWARD NJ. AMBULATORY TREATMENT OF VARICOSE STATE BY COMBINED LIGATION AND THROMBOSIS BY INJECTION: A STUDY IN END-RESULTS. Arch Surg. 1934;29(3):481–491. doi:10.1001/archsurg.1934.01180030146009
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