During the past decade increasing interest has been shown in the treatment of tumors of the pituitary gland by high voltage irradiation. Approximately twenty-six years ago, impetus was given to this form of treatment by Gramegna1 (1909), who was the first to report treatment by this method of a tumor of the pituitary gland. His patient, an acromegalic woman with rapidly failing vision, was given two courses of treatment in the years 1907 and 1908, respectively. The first was followed by some improvement in her vision, which later failed. She was not helped by the second course of treatment. He felt that the acromegalic features of the case were arrested. The radiation was given through the mouth, as being the nearest portal of entry to the pituitary gland and offering relatively little bony resistance to the rays. He felt that the mucous membranes tolerated irradiation as well as, or
RAND CW, TAYLOR RG. IRRADIATION IN THE TREATMENT OF TUMORS OF THE PITUITARY GLAND: REPORT OF TWENTY-THREE CASES. Arch Surg. 1935;30(1):103–150. doi:10.1001/archsurg.1935.01180070106007
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