Numerous methods have been devised for the experimental production of peptic ulcer in animals. In these experiments, spontaneous experimental peptic ulcer was produced in an intestinal fistula that extended from a gastric pouch to the abdominal wall. This method permits the investigation of phases of the problem which have not heretofore been touched on. As the ulcers were completely removed from the main gastro-intestinal tract, many confusing factors could be eliminated. Furthermore, the ulcers were easily accessible, so that various types of treatment could be applied directly to their surface.
In a preliminary report I1 outlined the factors that were responsible for the development of such an ulcer, the changes in the secretion in the pouch and a method of preventing or healing the ulcer. In this paper a more complete report will be made concerning the development of the ulcers, concerning mucosal susceptibility to the formation of the
HARPER FR. DEVELOPMENT AND TREATMENT OF PEPTIC ULCER: AN EXPERIMENTAL STUDY. Arch Surg. 1935;30(3):394–404. doi:10.1001/archsurg.1935.01180090025002
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