In its simpler form the typical pigmented spots on the skin and the multiple small subcutaneous nodules render neurofibromatosis easily recognizable. These characteristic changes, however, are not always present and at times are so overshadowed by other extensive and bizarre pathologic changes involving both the soft and the bony tissues that confusion in diagnosis may readily result. Numerous cases already reported, illustrating interesting changes of the skin, subcutaneous tissues, nervous system and skeleton, extend considerably the knowledge of the disease described by von Recklinghausen in 1882. To these a case of extensive involvement of the vertebral column leading to compression myelitis, with sarcomatous degeneration of more than one neurofibroma, seems worth adding.
REPORT OF A CASE
—H. M., a white boy aged 11 years, first came under observation in this department on March 12, 1924. The complaint was curvature of the spine, first noticed at 1 year of age,
MILLER A. NEUROFIBROMATOSIS: WITH REFERENCE TO SKELETAL CHANGES, COMPRESSION MYELITIS AND MALIGNANT DEGENERATION. Arch Surg. 1936;32(1):109–122. doi:10.1001/archsurg.1936.01180190112006
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