I have previously indicated1 that eosin tends to stain eroded areas in cartilage selectively; that is, the lesion in the cartilage is stained, but the surrounding normal cartilage is not. I know that this is true of such lesions in tissue examined soon after death. In experimental arthritic lesions produced in the knee joints of rabbits2 by traumatization of the cartilage of the knee joint with a large bore needle, no selective staining was observed with eosin or with any other dye used. The intensity of staining varies with the concentration of the dye, and the critical concentration at which the synovial membrane stains and the cartilage does not was observed to be a 0.05 per cent aqueous solution of eosin. Since I knew of no other dye with apparent selectivity, I have used only eosin for clinical work.
The pharmacologic behavior of eosin may account for its
BURMAN MS. THE INJECTION OF EOSIN INTO THE KNEE JOINT: ITS VALUE IN ARTHROSCOPY. Arch Surg. 1936;32(3):524–527. doi:10.1001/archsurg.1936.01180210153007
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