The literature contains few reports dealing with the sites of giant cell tumors long after operation, and there has been much curiosity as to the type of tissue filling the defects.
Herendeen1 reported a series of six cases observed for from five to ten years in which the diagnosis of giant cell tumor was made from roentgenograms only. After roentgen therapy the symptoms disappeared, but subsequent roentgenograms revealed considerable abnormalities still existing in the bony structure. Although varying degrees of filling in by cancellous bone had occurred several years after the patients first came under observation roentgenograms still showed a picture which was atypical of giant cell tumor. No biopsies had been performed during the follow-up periods.
The purpose of this report is to record an instance of benign giant cell tumor of the upper end of the tibia in which histologic studies were made on material removed at
WILLIAM F. BESWICK, ALEXANDER BRUNSCHWIG. SITE OF BENIGN GIANT CELL TUMOR ELEVEN YEARS AFTER OPERATION. Arch Surg. 1936;32(5):875–879. doi:10.1001/archsurg.1936.01180230130009