To Robert Meyer1 belongs the credit for the chapter on the special ovarian tumors related to sexual characteristics. Contrary to the old concept that neoplastic cells are nonfunctional, he has pointed out that neoplastic cells may have a specific functional capacity affecting intimately the life of the patient and productive of profound changes in his or her sex life. He grouped these tumors under the following headings: disgerminoma, granulosa cell tumor and arrhenoblastoma.
A disgerminoma occurs either in the testis or in the ovary, and the two types closely resemble each other. The tumor is carcinomatoid and usually results in pseudohermaphroditism. It is said to arise from undifferentiated forms of germinal cells which have lost their faculty for sex determination. It is usually found in young girls presenting hypoplasia and underdevelopment of the genitalia. It may occasionally occur also in boys, and a group of tumors is usually present,
BEHREND M, LEVINE S. ARRHENOBLASTOMA OF THE OVARYTESTICULAR ADENOMA TUBULARE. Arch Surg. 1936;33(3):392–396. doi:10.1001/archsurg.1936.01190030045002
Customize your JAMA Network experience by selecting one or more topics from the list below.