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Article
October 1936

EXPERIMENTAL PULMONARY ABSCESS: II. TRANSMISSION OF THE DISEASE TO DOGS BY THE BRONCHIAL ROUTE

Author Affiliations

SAN FRANCISCO
From the Research Laboratories and the Department of Pathology of the Mount Zion Hospital and the Division of Thoracic Surgery of the University of California, service of Dr. Harold Brunn.

Arch Surg. 1936;33(4):649-663. doi:10.1001/archsurg.1936.01190040107007
Abstract

Surgeons who have devoted many years to the study of pulmonary abscess are confronted with numerous difficulties in the diagnosis and treatment of this disease.1 Any aid which the laboratory can furnish will necessarily depend on an increase in the knowledge of its etiology and pathogenesis.

In another communication2 a method is described for the experimental production of pulmonary abscess in Java monkeys (Macacus irus) by the bronchial route. Pus from guinea-pigs containing various anaerobic bacteria, including several types of fusiform bacilli, Bacterium melaninogenicum, anaerobic nonhemolytic streptococci, gram-negative motile rods of the Bacteroides group and spirochetes, was injected intrabronchially and the corresponding bronchus was then blocked by means of a plug of agar. Of fourteen monkeys thus treated, large abscesses developed in six, pneumonia with several small abscesses of the lung in one and pneumonia and purulent bronchitis with bronchiectasis in one. The remaining animals were essentially normal.

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