The purpose of this report is to examine various clinical practices in the use of spinal anesthesia and the assumption concerning them in the light of facts accumulated in a four year study on experimental spinal anesthesia in the dog. The following topics will be discussed: (1) the effect of the narcotic agent on the respiratory center; (2) the use of narcotics as premedication, (3) the effect of a stimulating drug (a 25 per cent solution of pyridine betacarbonic acid di-ethylamide) on paralysis of the respiratory center, produced by procaine hydrochloride, (4) the fall in blood pressure and its cause, effects and treatment, and (5) the use of carbon dioxide as a stimulant.
EFFECT OF THE NARCOTIC AGENT ON THE RESPIRATORY CENTER
In a previous communication,1 it was shown that if procaine hydrochloride is made to reach the medulla in sufficient strength, either by injection into the cisterna magna
CoTUI. SPINAL ANESTHESIA: THE EXPERIMENTAL BASIS OF SOME PREVAILING CLINICAL PRACTICES. Arch Surg. 1936;33(5):825–847. doi:10.1001/archsurg.1936.01190050094005
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