In 1935 I began an experimental study relative to abdominal adhesions, which work when completed encompassed data obtained from certain clinical observations and from 145 operations or autopsies on 55 animals.1 Since permanent abdominal adhesions were created in a number of these animals, I decided to use some of them for investigating the efficacy of papain as a preventive of the reformation of adhesions. Accordingly, an analysis of relevant data obtained from the foregoing work was correlated with additional experimentation with papain.
To evaluate the data in this paper properly, it is necessary to review briefly the history of proteolytic ferments as they have been used in attempts at prevention of adhesions. A number of investigations in this regard have been made in the last twenty-five years relative to the prophylactic or curative value of pepsin, trypsin and papain. Some investigators have felt that the first two substances were
DONALDSON JK. ABDOMINAL ADHESIONS AND THE USE OF PAPAIN: A DISCUSSION AND AN EXPERIMENTAL STUDY. Arch Surg. 1938;36(1):20–27. doi:10.1001/archsurg.1938.01190190023002
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