In 1880 Billroth made the statement that if any one could find a solution that would produce artificial proliferation of tissue the problem of the radical surgical treatment of hernia would be solved. In recent years Hall,1 Wolfe,2 Mayer,3 Bratrud,4 Rice,5 Quillin,6 Fowler,7 La Rochelle8 and many others have reported clinical cures with the injection of different sclerosing solutions in selected cases of hernia, without any serious complications. The only experimental studies of the effects of some of the solutions used have been made by Hall, Wolfe, Rice and Bratrud. Hall, using dogs, guinea-pigs and monkeys, injected from 1 to 5 cc. of Piña Mestre's solution into the abdominal muscles daily for from five to six days and found at the end of that time a marked proliferation of fibroblasts and endothelial cells with many foreign body giant cells. Sections of tissue
MANOIL L. HISTOLOGIC EFFECTS OF VARIOUS SCLEROSING SOLUTIONS: USED IN THE INJECTION TREATMENT OF HERNIA. Arch Surg. 1938;36(2):171–189. doi:10.1001/archsurg.1938.01190200003001
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