—Wolfe44 stated that routine cystoscopic examination has revealed tumor of the bladder as an occupational disease in workers exposed to benzidine, alphanaphthylamine and betanaphthylamine but not in those exposed to aniline. Analysis of the records of 2,868 routine cystoscopic examinations and of 83 cases of tumor of the bladder indicates that history and symptomatology are of little aid in diagnosis. Constant exposure to the cancerigenic agent is the important factor in the development of tumor of the bladder. Routine cystoscopic examination is the most important procedure in the medical control of the so-called aniline tumor of the bladder.Ferguson,45 in discussing aniline tumor of the bladder, stated that he believed that the pathogenesis of multiple papillomatosis of the bladder, both occupational and nonoccupational, is the result of the circulation, a cancerigenic agent in the blood. Because of this, he expressed the belief that the entire bladder
SCHOLL AJ, HINMAN F, von LICHTENBERG A, et al. A REVIEW OF UROLOGIC SURGERY. Arch Surg. 1938;36(3):531–560. doi:10.1001/archsurg.1938.01190210160011
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