In an earlier series of four papers we presented a brief account of our experience up to October 1933 in the treatment of infections due to hemolytic streptococci by use of the concentrated antistreptococcus serum of the New York state department of health. Our results at that time indicated a favorable effect of the serum, although the observations were not regarded as conclusive. We quote a paragraph from the first of these papers:1
In some diseases the natural course of the malady, when uninfluenced by therapeutic meddling, tends to follow a more or less definite schedule and to terminate in recovery or in death. In other disorders the course tends to be variable, and the complications and the eventual outcome are lacking in uniformity. Infections with the hemolytic streptococci belong in the latter category. On that account the appraisal of any therapeutic agent for streptococcic infections is made difficult,
SHEPLAR AE, SPENCE MJ, MacNEAL WJ. SERUM THERAPY FOR INFECTIONS WITH STREPTOCOCCI: GENERAL OBSERVATIONS. Arch Surg. 1938;37(5):772–789. doi:10.1001/archsurg.1938.01200050078006
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