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January 1939


Author Affiliations

From the service of Dr. E. MacD. Stanton and Dr. Charles W. Woodall, Ellis Hospital.

Arch Surg. 1939;38(1):181-190. doi:10.1001/archsurg.1939.01200070184014

In 1896 Frederick von Krukenberg described a rare type of ovarian tumor of which he had seen 5 instances. The tumor presented certain characteristics of form and growth not seen in other ovarian tumors. It affected both ovaries and was solid; it was actually accompanied by ascites and was free from adhesions. Histologically it had a fibrosarcomatous-appearing stroma which enclosed large cells with a mucoid-like protoplasm. Often these cells had a nucleus displaced to the periphery, which gave them a "signet ring" appearance. Von Krukenberg believed the tumor to be a form of sarcoma and christened it "fibrosarcoma ovarii mucocellulare." The comparative rarity of the Krukenberg tumor is shown by the scant number which have been reported in the medical literature. Masson1 in 1934 reported 5 cases observed at the Mayo Clinic from 1909, although he stated that in earlier files there are records of other tumors which might