Although Reil1 described the first case of agenesis of the corpus callosum as early as 1812, the apparent rarity of the condition is indicated by the fact that Baker and Graves,2 reviewing the literature in 1933, discovered only 81 reported cases, to which they added 1 of their own. Of the 82 cases, only 2 were reported in the United States. Archambault,3 in 1911, described a case of complete agenesis. In the case reported by Baker and Graves the agenesis was partial.
Until the introduction of ventriculography in 19184 and encephalography in 19195 by Dandy there was no method of diagnosing the condition during life, and for this reason agenesis of the corpus callosum was invariably discovered unexpectedly at autopsy.
Apparently Guttmann6 made the first encephalographic study of this condition in 1929. His description of the encephalographic picture was typically that of agenesis of
CASS AB, REEVES DL. PARTIAL AGENESIS OF THE CORPUS CALLOSUMDIAGNOSIS BY VENTRICULOGRAPHIC EXAMINATION. Arch Surg. 1939;39(4):667–681. doi:10.1001/archsurg.1939.01200160157010
Customize your JAMA Network experience by selecting one or more topics from the list below.