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October 1939


Author Affiliations

Dr. Risk died March 21, 1938.; From the Physiological Laboratories, the University of Chicago.

Arch Surg. 1939;39(4):686-690. doi:10.1001/archsurg.1939.01200160176012

The subject of wound healing of all types was thoroughly reviewed by Arey in 1936.

Modern therapy for burns attempts to alleviate the subsequent toxemia and secondary shock of severe burns by rendering any supposed toxins arising from the heat-killed tissue insoluble. For many reasons, the conditions for healing under the coagulum of chemically coalesced debris do not approach the optimum conditions existing under the natural fibrin eschar (Carrel; Carrel and Baker1).

The possibility of obtaining more rapid healing by providing a more nearly ideal physiologic environment for the wounded area led to the following study on rats, in which a comparative evaluation of various therapeutic agents and methods used as controls has been undertaken.

METHOD  An experimental humidity chamber with a wood frame and glass windows, measuring 6 feet (180 cm.) long, 3 feet (90 cm.) wide and 3 feet (90 cm.) high, with a displacement of 54

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