In 1930, Kay1 observed a rise in the level of serum phosphatase following fracture and suggested that this might be on the basis of increased local production of phosphatase. McKeown and Ostergren2 studied the phosphatase activity in healing fractures in albino rats. They found a rise in osseous phosphatase during callus formation and a fall during development of the medullary space. Peden3 followed the concentration of plasma phosphatase in healing fractures in children and found a rise during the first few days, followed by a fall. Gutman, Sproul and Gutman4 found increased phosphatase activity at the site of osteoplastic metastases secondary to carcinoma of the prostate. Botterell and King5 studied changes in callus and blood phosphatase in rabbits. They found an increase at the site of fracture which lasted fifty to sixty days. This was seen to be related to the degree of osteoblastic activity
TOLLMAN JP, DRUMMOND DH, McINTYRE AR, BISGARD JD. TISSUE METABOLISM AND PHOSPHATASE ACTIVITY IN EARLY CALLUS. Arch Surg. 1940;40(1):43–48. doi:10.1001/archsurg.1940.04080010046005
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