In the course of experimental work on surgical infections it seemed necessary to study anew the temperature responses of the body to acute inflammations and infections. For our own purposes it was desirable to observe the relation between the deep temperatures of the brain, liver, rectum and muscles in the normal subject; the variations in deep temperature as influenced by the commonly used anesthetic drugs; the time of appearance of elevation of temperature in the tissues involved and in the intra-abdominal organs and the brain after production of an acute localized inflammation; the reliability of the rectal temperature as a guide to the febrile state of the subject, and the relation between leukocytic response and elevation of temperature. Observations of this sort have, of course, repeatedly been made, but such observations and their interpretations as published in the literature have varied greatly. As a preliminary study it appeared desirable to
HEUER GJ, CONWAY H. REGIONAL AND GENERAL TEMPERATURE RESPONSE FOLLOWING EXPERIMENTALLY INDUCED ACUTE INFLAMMATION AND INFECTION. Arch Surg. 1940;40(5):917–928. doi:10.1001/archsurg.1940.04080040099010
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