PURPOSE OF THIS INVESTIGATION
The secretion of fluid by the appendix of man, the chimpanzee and the rabbit and the development of appendicitis consequent to obstruction of the appendical lumen in these species have been reported.1 Twenty-four other species of animals have failed to show either secretion of fluid or development of appendicitis following obstruction by ligation.2The rabbit has proved so useful an animal in which to study the effects of appendical obstruction that it is believed worth while to outline the results of the experiments which have been done on this species. Further, it is possible in the rabbit, in which the functional behavior of the cecal appendage in many respects is not unlike that of the vermiform process of man, to make controlled observations which cannot be done on man, and such observations also are of the greatest value in promoting understanding of the effects
DENNIS C, BUIRGE RE, VARCO RL, WANGENSTEEN OH. STUDIES IN THE ETIOLOGY OF ACUTE APPENDICITIS: AN INQUIRY INTO THE FACTORS INVOLVED IN THE DEVELOPMENT OF ACUTE APPENDICITIS FOLLOWING EXPERIMENTAL OBSTRUCTION OF THE APPENDICAL LUMEN OF THE RABBIT. Arch Surg. 1940;40(5):929–948. doi:10.1001/archsurg.1940.04080040111011
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