The role played by the digestive juices in the causation of peptic ulcer has long been under investigation. The acid "gastric chyme" has been studied by a variety of methods, and from the results obtained many investigators have delegated to it the role of villain in the drama of the pathogenesis of ulcer. From this point of view, interest was aroused in possible mechanisms or substances which might normally "protect" against ulcer formation. Among these, attention has been centered on the alkaline digestive juices—the succus entericus, the pancreatic juice and the bile. Attempt has been made to evaluate the "protective" qualities of these secretions in toto, singly and in various combinations.
Most previous work has been done by means of the Mann-Williamson preparation, whereby "duodenal drainage" is instituted and then single or combined alkaline juices are reshunted to the upper part of the intestinal tract in an attempt to evaluate
SWAN H. EFFECT OF CHOLECYSTOGASTROSTOMY ON CINCHOPHEN-PRODUCED ULCER IN DOGS. Arch Surg. 1940;41(3):569–584. doi:10.1001/archsurg.1940.01210030003001