The phrase "locus minoris resistentiae" is hoary with years, and the initiation of local infective processes by injury unaccompanied with direct infection is a widely recognized fact.1 Streptococci, when given intravenously, have been observed to localize in abscesses produced by subcutaneous injection of silver nitrate.2 Benians3 found that Bacillus typhosus, when injected intravenously in rabbits, localized in areas of skin where agar, mucin and starch had previously been injected. Tubercle bacilli, when present in the blood stream, tend to localize in areas of necrosis and also in tissue showing an increase in vascularity.4 As early as 1843, Cazenave5 observed that localization of a secondary syphilitic lesion is commonly determined by some concomitant irritation or morbid condition.
Findlay,6 in 1928, studied the problem of localization of bacteria in areas of injury. He stated:
When bacteria are present in the blood stream, their passage through the
RIGDON RH. LOCALIZATION OF STAPHYLOCOCCI IN AREAS OF INFLAMMATION PRODUCED BY XYLENE. Arch Surg. 1940;41(4):879–887. doi:10.1001/archsurg.1940.01210040068004
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