A water-soluble compound with vitamin K activity, 4-amino-2-methyl-1-naphthol hydrochloride, has been synthesized by Doisy and his associates.1 The oil-soluble vitamin K, 2-methyl-1,4-naphthoquinone, has been found very active when administered orally,2 but since it is relatively insoluble in water, it is inconvenient for parenteral use. Parenteral administration of vitamin K has several advantages over oral administration. By the oral route, there may be a lack of absorption due to intestinal obstruction, paralytic ileus or some other intestinal complication. By the parenteral route the vitamin may be given to patients who are unable to take it orally because of nausea or vomiting. In the treatment of hemorrhagic disease of the newborn, for which vitamin K is very effective, the parenteral method is especially indicated. When the substance is administered parenterally it is not necessary to give bile salts. With oral administration bile salts must be present in order to assure
ANDERSON ER, KARABIN JE, UDESKY H, SEED L. PARENTERAL ADMINISTRATION OF A WATERSOLUBLE COMPOUND WITH VITAMIN K ACTIVITY: 4-AMINO-2-METHYL-1-NAPHTHOL HYDROCHLORIDE. Arch Surg. 1940;41(5):1244–1250. doi:10.1001/archsurg.1940.01210050204012
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