A description of the method used and the values for circulation time obtained with normal subjects and under various physiologic conditions have been presented in another communication.1 The method consists of determining the time elapsing between the injection of a 2 per cent solution of sodium cyanide into an antecubital vein or into a vein of the foot and the appearance of rapid dilatation of the alae of the nose, followed by an inspiratory gasp and then by tachypnea. Ordinarily 0.11 mg. of sodium cyanide was injected for each kilogram of body weight when the circulation time from the arm to the carotid sinus was studied, and twice this amount was injected when the circulation time from the foot to the carotid sinus was studied. However, if the respiratory response was excessive when the time from the arm to the carotid sinus was determined, 1 mg. was deducted from
SMITH LA, ALLEN EV. CIRCULATION TIME FROM FOOT TO CAROTID SINUS AND FROM ARM TO CAROTID SINUS OF MAN: II. EFFECTS OF OPERATION AND OF ADMINISTRATION OF THYROID GLAND; POSTOPERATIVE PHLEBITIS AND PULMONARY EMBOLISM. Arch Surg. 1940;41(6):1377–1393. doi:10.1001/archsurg.1940.01210060074008
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