Many studies on bile and its constituents have been made in the past. Most of these have been directed simply to determining the absolute amounts of the various constituents. In man, these studies have been of three types: (1) on gallbladder bile taken at operation; (2) on bile taken postoperatively from a hepatic fistula, and (3) on gallbladder bile taken post mortem. Comparisons have been made between the first and second and between the second and third types of determination. That any of the determinations are truly physiologic may be debated—the very fact that operation on the biliary tree was required impugns the validity of the results. McNee1 pointed out that most results and methods are unsatisfactory. The present study differs from the former ones in that the hepatic bile used for these determinations was taken at the same time as the gallbladder bile in cases in which operation
LLOYD SJ. COMPARATIVE CONCENTRATION OF HUMAN HEPATIC BILIRUBIN AND CHOLESTEROL BY THE GALLBLADDER: A POSTMORTEM STUDY. Arch Surg. 1940;41(6):1494–1504. doi:10.1001/archsurg.1940.01210060191015
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