—Rusche and Hager48 presented some observations on the development of malignancy in Hunner's ulcer, and they reported 2 cases.In 1 case the patient was a man aged 26 years, in whom definite Hunner's ulcer was found. Treatment consisted of the usual measures. Fifteen years later he was again examined. He was in a critical condition at this time and died shortly afterward. Cystoscopic examination had not been made. Microscopic examination of the wall of the bladder showed a definite carcinoma. The tumor was anaplastic, and a growth infiltrated the tissues. It resembled a scirrhous neoplasm, such as might have been found in the presence of gastric carcinoma.In the second case the patient was a woman 65 years old who was seen in 1933, at which time several irregular portions 1 cm. in diameter had been seen in the posterior wall of the bladder during
SCHOLL AJ, HINMAN F, VON LICHTENBERG A, et al. REVIEW OF UROLOGIC SURGERY. Arch Surg. 1940;41(6):1505–1532. doi:10.1001/archsurg.1940.01210060202016
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