Physicians seldom consider carcinoma of the gallbladder a factor of much significance when advising patients with gallstones regarding their management. Repeated emphasis has made the members of the medical profession aware of the possibility of malignant growth developing in some other sites of the body in connection with certain types of lesions. For example, when the roentgenologist reports an ulceration on the gastric side of the pylorus in a person with ulcer dyspepsia, nearly every physician knows the implications as far as malignant growth is concerned. In contrast to this, persons with gallstones are rarely thought of as having or as likely to have a carcinoma of the gallbladder.
Five cases of primary carcinoma of the gallbladder have been observed in a year and a half, and 4 of these were observed within six months. There was only 1 case in which the presence of a malignant tumor was suspected
GREENLEE DP, HAMILTON RC, FERRARO FP. PRIMARY CARCINOMA OF THE GALLBLADDER. Arch Surg. 1941;42(3):598–610. doi:10.1001/archsurg.1941.01210090147013
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