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Article
April 1941

CHANGES IN THE LIVER ASSOCIATED WITH HYPERTHYROIDISMWITH A STUDY OF PLASMA PROTHROMBIN LEVELS IN THE IMMEDIATE POSTOPERATIVE PERIOD

Arch Surg. 1941;42(4):643-660. doi:10.1001/archsurg.1941.01210100003001
Abstract

During the past nine years considerable interest has been aroused concerning the state of the liver in patients with hyperthyroidism, and excellent studies of the morphologic and physiologic changes in this organ associated with increased activity of the thyroid gland have been reported. Despite the evidence of such a possible relation, however, many patients with hyperthyroidism are treated without regard for hepatic function so far as the type of diet is concerned. Attention has been focused on a high caloric intake, with disregard of the carbohydrate-fat ratio and the vitamin requirements.

ANATOMIC CHANGES  Cameron and Karunaratne1 have summarized the development of knowledge concerning the hepatic changes accompanying hyperthyroidism, and Boyce and McFetridge2 have reviewed the significant clinical and pathologic contributions which have been made to this subject in recent years.In 1932, Weller,3 in studying the morphologic changes in the livers of 48 patients who died with

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