More than three fourths of all gallbladders removed contain stones, which are thought by many to cause symptoms invariably.1 Removal of the gallbladder results in relief of symptoms in 90 to 95 per cent of cases.2 Gross disease of the gallbladder without stones, so-called acalculous cholecystitis, also probably causes symptoms in the majority of cases, and removal of the organ is attended by relief of symptoms in 80 to 90 per cent.2a A third type of gallbladder occasionally encountered at operation for clinically diagnosed disease of the gallbladder contains neither stones nor any other macroscopic evidence of disease. It is this type of gallbladder with which the present report is concerned. Judd and his associates have remarked, "such cases constitute one of the major therapeutic problems of biliary surgery."2a Although results in the individual case are unpredictable, it has been found empirically that removal of such
DOEHRING PC. MACROSCOPICALLY NONPATHOLOGIC GALLBLADDERA CLINICOPATHOLOGIC STUDY. Arch Surg. 1941;42(4):665–680. doi:10.1001/archsurg.1941.01210100025003
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