Observations on the mechanism of capillary permeability and its relation to inflammation have been the basis for a series of papers by one of us. In these it has been shown that the phenomenon considered to be an increase in capillary permeability as indicated by the localization and concentration of trypan blue following an intravenous injection represents a change which apparently occurs in the epithelial cells, connective tissue cells and endothelial cells after either injection or application of any one of many different types of irritants.1 This increase in permeability represents a temporary change in the cells, as shown by the localization and concentration of trypan blue in the skin of the rabbit for only three hours after the local application of xylene. The greatest quantity of trypan blue localizes in the area where xylene is applied the shortest time before the dye is given.2
The time in
RIGDON RH, WILSON H. CAPILLARY PERMEABILITY AND INFLAMMATION IN RABBITS GIVEN HEPARIN. Arch Surg. 1941;43(1):64–73. doi:10.1001/archsurg.1941.01210130067005
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