Individual clinical reports (Stevens;1 Meakins2) are to be found in the literature of decrease or complete absence of gastric acidity in patients with moderate or severe damage to the liver, irrespective of the cause of the damage. One is also familiar with individual analyses of the gastric contents of patients treated for malignant tumor of the stomach or of the kidney in whom large sections of the liver have been damaged secondarily by irradiation; in these studies, too, the recorded values for acidity are definitely lower than the average normal.
It seemed that a systematic study of the effect of damage to the liver on the gastric acidity response was warranted.
Dogs were used for these experiments. Damage to the liver was produced experimentally in two ways: (1) by direct high voltage irradiation of the liver and (2) by intragastric administration of carbon tetrachloride in milk. The
STREICHER MH. EFFECT OF HEPATIC DAMAGE ON GASTRIC ACIDITY. Arch Surg. 1941;43(1):74–87. doi:10.1001/archsurg.1941.01210130077006